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Genome-wide association studies: inherent limitations and future challenges
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 444-450 doi: 10.1007/s11684-012-0225-3
Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic architecture. Recently, GWAS is quite the fashion in China. However, there are issues related to its nature. Enormous work needs to be done in the post-GWAS era. Deep sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical practice. Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized medicine. In this article, we used hepatocellular carcinoma (HCC) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.
关键词: genome-wide association studies (GWAS) genetic variant cancer limitation challenge
A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
《医学前沿(英文)》 2023年 第17卷 第2期 页码 330-338 doi: 10.1007/s11684-022-0933-2
关键词: Clouston syndrome whole exome sequencing GJB6 gene novel variant unique phenotype
《医学前沿(英文)》 2023年 第17卷 第3期 页码 493-502 doi: 10.1007/s11684-022-0946-x
关键词: ALK fusion next-generation sequencing fluorescence in situ hybridization immunohistochemistry variant allele frequency intratumoral heterogeneity targeted therapy
Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant
《医学前沿(英文)》 2023年 第17卷 第3期 页码 576-580 doi: 10.1007/s11684-023-0991-0
关键词: variant
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in
《医学前沿(英文)》 2022年 第16卷 第5期 页码 808-814 doi: 10.1007/s11684-021-0878-x
关键词: epidermolysis bullosa LAMA3 COL7A1 KRT5 Chinese families
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
《医学前沿(英文)》 2023年 第17卷 第4期 页码 768-780 doi: 10.1007/s11684-023-0982-1
关键词: machine learning methods hypertrophic cardiomyopathy genetic risk
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 319-323 doi: 10.1007/s11684-017-0553-4
Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venous thromboembolism (VTE). Here, we report a Chinese 22-year-old young man who developed recurrent and serious VTE in cerebral veins, visceral veins, and deep veins of the lower extremity. Laboratory tests and direct sequencing of and were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variant c.572_574delAGA in . This combination of the two mutations was absent in 400 healthy subjects each from southern and northern China. Then, we summarized all the mutations of the and gene reported in the Chinese Han population. This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity can result in severe VTE and that the coexistence of different genetic factors may increase the risk of VTE.
关键词: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
Exergy and exergoeconomic analyses for integration of aromatics separation with aromatics upgrading
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 183-193 doi: 10.1007/s11705-022-2192-9
关键词: aromatics separation and upgrading variant splitting ratios total exergy destruction total product unit cost
Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN
《农业科学与工程前沿(英文)》 2015年 第2卷 第3期 页码 216-222 doi: 10.15302/J-FASE-2015072
关键词: pseudorabies virus glycoprotein B protein subunit vaccine
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
《医学前沿(英文)》 2018年 第12卷 第6期 页码 601-607 doi: 10.1007/s11684-018-0648-6
The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
《结构与土木工程前沿(英文)》 2019年 第13卷 第4期 页码 863-889 doi: 10.1007/s11709-019-0523-9
关键词: design optimization genetic algorithm multiple populations neural network
Research progress on genetic improvement of
Chuanping YANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第4期 页码 391-401 doi: 10.15302/J-FASE-2017183
关键词: Betula platyphylla genetic improvement molecular breeding seed orchard
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 305-318 doi: 10.15302/J-FASE-2017154
Search-and-replace editing of genetic information
Yao LIU, Xingxu HUANG, Xiaolong WANG
《农业科学与工程前沿(英文)》 2020年 第7卷 第2期 页码 231-232 doi: 10.15302/J-FASE-2020322
Age-related trends in genetic parameters for wood properties in
Chao SUN, Meng LAI, Shougong ZHANG, Xiaomei SUN
《农业科学与工程前沿(英文)》 2017年 第4卷 第4期 页码 482-492 doi: 10.15302/J-FASE-2017184
关键词: early selection genetic variation wood properties SilviScan Larix kaempferi
标题 作者 时间 类型 操作
A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
期刊论文
Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy
期刊论文
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in
期刊论文
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
期刊论文
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report
null
期刊论文
Exergy and exergoeconomic analyses for integration of aromatics separation with aromatics upgrading
期刊论文
Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus variant
Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN
期刊论文
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
期刊论文
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
期刊论文
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
期刊论文